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A Randomized Clinical Trial of Low-dose Cannabis Extract in Alzheimer’s Disease

By |December 20, 2025|Alzheimer's Disease|

A Randomized Clinical Trial of Low-dose Cannabis Extract in Alzheimer’s Disease

The Chiro.Org Blog


SOURCE:   J Alzheimers Dis 2025 (Dec); 108 (4): 1602–1613

Rafael de Morais Cury • Taynara da Silva • Fernando Cezar-Dos-Santos • Yasmin Rafaela Correia Fakih • Karlin Andrea Ramírez Narvaez • Murilo Chaves Gouvea • Carlos Espínola • Charles Francisco Ferreira • Wagner Antonio Chiba de Castro • Fabrício Alano Pamplona • Elton Gomes da Silva • Maíra Assunção Bicca • Francisney Pinto Nascimento

Laboratório de Cannabis e Psicodélicos,
School of Medicine,
Universidade Federal da Integração Latino-Americana,
Foz do Iguaçu, PR, Brazil.




SOURCE:   The Conversation


Background:   Preclinical and clinical evidence suggest that low-dose cannabinoids could ameliorate Alzheimer’s disease (AD) signs and symptoms. We designed this trial to evaluate the safety and efficacy of low-dose THC-CBD balanced cannabinoid extract in the treatment of patients with AD-associated dementia.

Objective: The objective of this phase 2 trial was to evaluate the safety and efficacy of a balanced THC-CBD cannabinoid extract for symptomatic patients with AD.

Methods: A Phase 2, randomized, double-blind, placebo-controlled, clinical trial including patients between 60 and 80 years-old diagnosed with AD-associated dementia. For 26 weeks, participants orally received either placebo or THC-CBD extract (0.350 mg/THC and 0.245 mg/CBD), daily.

Results: At week 26, Mini-Mental State Exam total score was significantly higher in cannabis- when compared to placebo-treated patients, which was assessed using the mixed model analysis. No significant difference was detected between placebo and cannabis groups in terms of secondary outcomes and adverse events incidence.

Conclusions: To this date, this is the longest clinical trial evaluating cannabinoids effects on AD patients. We initially demonstrate that low-dose THC-CBD potentially can be an effective and safe therapeutic option for AD-related dementia. Nonetheless, larger and longer trials are necessary to confirm this finding and establish cannabinoid administration as therapy for AD dementia.

Keywords: Trial RegistrationThe Brazilian Registry of Clinical Trials (ReBEC) registration #U1111-1258-2058 – REBEC (ensaiosclinicos.gov.br).

Keywords:   Alzheimer’s disease; Mini-Mental State Examination; cannabinoids; dementia; memory.

ACA Applauds Congress for Initial Step to Restore Chiropractic at Select Military Bases

By |December 19, 2025|Veterans|

ACA Applauds Congress for Initial Step to Restore Chiropractic at Select Military Bases

The Chiro.Org Blog



FOR IMMEDIATE RELEASE: Dec. 18, 2025


Arlington, Va. — The U.S. House of Representatives and Senate have passed the final version of the Fiscal Year 2026 National Defense Department Authorization Act, which includes a plan to restore chiropractic services at six U.S. military bases where services have been arbitrarily discontinued. The six clinics that will be reopened include those seeing 400 or more patients per month.

The final provision also calls on the Defense Health Agency (DHA) to develop a plan to reopen closed clinics and to explore the feasibility of putting doctors of chiropractic stationed at military facilities in the federal General Schedule (GS) system. Further, the amendment directs DHA to report back to the House and Senate on its progress by March 31, 2026.

The move to restore chiropractic services is consistent with the DHA’s ongoing concern over the use of opioids by active-duty members of the military and calls to make non-addictive alternatives for pain management more readily available to military personnel. The final language was first adopted in September as an amendment by Rep. Greg Steube (R-Fla.) to the House version of the bill. It reflects upon the Floyd D. Spence National Defense Authorization Act (Public Law 106-398), which in 2001 established the original chiropractic benefit in the Department of Defense healthcare system.

We thank Rep. Steube for his foresight to tackle this issue, and we also acknowledge House and Senate negotiators who kept the bulk of his amendment in the final package,” said John Falardeau, American Chiropractic Association (ACA) senior vice president of public policy and advocacy.

The Steube amendment was drafted in response to chiropractic clinic closures over the past year caused by contracts with participating chiropractors being allowed to lapse, even though surveys indicate chiropractic services are highly valued at U.S. military facilities. Reports show that these clinics provide proven, cost-effective care to hundreds of patients monthly, offering a range of non-drug services to address painful musculoskeletal conditions commonly experienced by members of the military, enabling them to return to service. The results of a four-year clinical trial conducted at several military sites—the largest chiropractic clinical trial on record—provided further evidence that chiropractic care, when added to usual medical care, resulted in moderate short-term improvements in low back pain intensity in active-duty personnel.

The Fiscal Year 2026 National Defense Department Authorization Act now heads to the president’s desk for his signature. ACA will continue to work with Congress to ensure all military clinics that were recently closed reopen and to expand access at additional bases across the country and overseas.

About the American Chiropractic Association

The American Chiropractic Association (ACA) is the largest professional chiropractic organization in the United States. ACA attracts the most principled and accomplished chiropractors, who understand that it takes more to be called an ACA chiropractor. We are leading our profession in the most constructive and far-reaching ways—by working hand in hand with other health care professionals, by lobbying for pro-chiropractic legislation and policies, by supporting meaningful research and by using that research to inform our treatment practices. We also provide professional and educational opportunities for all our members and are committed to being a positive and unifying force for the practice of modern chiropractic. To learn more, visit acatoday.org.

ACA, ABCA, SCU Announce 2026 Collaborative Student Leadership Conference

By |December 10, 2025|Uncategorized|

ACA, ABCA, SCU Announce 2026 Collaborative Student Leadership Conference

The Chiro.Org Blog


SOURCE:   ACA ~ FOR IMMEDIATE RELEASE: Dec. 10, 2025

Annette Bernat
abernat@acatoday.org
(703) 812­-0226


Arlington, Va. — The American Chiropractic Association (ACA), the American Black Chiropractic Association (ABCA), and Southern California University of Health Sciences (SCU) will unite to host a collaborative Student Leadership Conference in 2026. The event, scheduled for late September, represents a significant opportunity for student leaders to connect, develop their leadership skills, and strengthen pathways that support the future of chiropractic.

“This joint effort is an opportunity to nurture connections between our leaders and members, strengthening the future of chiropractic,” said ACA President Marc Nynas, DC. “I’m excited to see ACA and ABCA come together for a collaborative Student Leadership Conference hosted by SCU.”

“Collaboration is essential for the growth of our profession,” added ABCA President Brandi Childress, DC. “Bringing our organizations together will open new doors and create opportunities that support greater representation and leadership development within the chiropractic community.”

SCU will welcome student leaders to its campus for four days of programming designed to inspire and empower the next generation of chiropractic professionals. “SCU is honored to host this historic meeting, and we are excited by the knowledge students will gain from it and from each other,” said SCU President John Scaringe, DC, EdD.

ACA’s annual Student Leadership Conference has long served as a valuable opportunity for education, networking, and mentorship for student members of ACA (SACA). Students engage directly with leading voices in the profession and gain exposure to leadership models that inform their academic and professional growth. ABCA plays an essential role in fostering diversity in the chiropractic field and providing a strong and distinct voice for Black chiropractic students and doctors. Its participation in the conference expands access, representation, and collaborative learning for all attendees.

The partnership reflects a shared commitment by ACA, ABCA, and SCU to advance leadership, innovation, and unity within chiropractic education. Additional conference details will be announced in the coming months.

About the American Chiropractic Association

The American Chiropractic Association (ACA) is the largest professional chiropractic organization in the United States. ACA attracts the most principled and accomplished chiropractors, who understand that it takes more to be called an ACA chiropractor. We are leading our profession in the most constructive and far-reaching ways—by working hand in hand with other health care professionals, by lobbying for pro-chiropractic legislation and policies, by supporting meaningful research, and by using that research to inform our treatment practices. We also provide professional and educational opportunities for all our members and are committed to being a positive and unifying force for the practice of modern chiropractic. Visit acatoday.org.

About the American Black Chiropractic Association

The mission of the American Black Chiropractic Association (ABCA) is to integrate and improve outcomes for persons of color entering the Doctor of Chiropractic profession. Our primary purpose is to recruit, encourage, and support Black individuals in the study of chiropractic, and to encourage research contributing to the science, philosophy, and art of the field. Furthermore, we assist chiropractic colleges in recruiting qualified Black students and faculty. As chiropractic is a growing field, we aim to improve professional standards, provide continuous community education, and maintain the Harvey Lillard Scholarship and Endowment Fund to support the educational growth of members of the Student American Black Chiropractic Association. Visit abcachiro.com.

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Patient Experience and Satisfaction with Chiropractic Care: A National Survey

By |November 30, 2025|Patient Satisfaction|

Patient Experience and Satisfaction with Chiropractic Care: A National Survey

The Chiro.Org Blog


SOURCE:   BMC Health Serv Res 2025 (Nov 26)
Line Lyskjær • Werner Vach • Casper Nim • Steen Harsted • Marlene Øllegaard Terkelsen • Rikke Krüger Jensen

Chiropractic Knowledge Hub,
Odense, Denmark



Background   Patient experience and satisfaction are important to stakeholders in the healthcare system, including payers, providers and patients. This study explores the patient experience and satisfaction with chiropractic care in Denmark including how aspects of patient experience and patient characteristics influence overall satisfaction.

Methods   A national survey was conducted over a two-week period in January 2023, targeting patients in all chiropractic clinics in Denmark. Clinics were asked to invite all patients to participate. Enrolled participants completed an electronic survey, containing 28 items on patient experience and satisfaction (5-point Likert scale). Associations of aspects of patient experience and patient characteristics with overall satisfaction were analysed with ordinal regression. Variation across clinics was analysed by forest plots and random effect models.

Results   Of the 250 clinics invited, 228 clinics (91%) recruited 27,577 patients for the survey (invitation rate of 53%). Of these, 17,974 (65%) were included in the final analysis. Patients reported ‘very high’ or ‘high’ degree of overall satisfaction with care (97%). Overall satisfaction was associated with personal experiences involving the chiropractor, particularly in the areas of examination and communication, patient involvement and information, and perceived effectiveness and reassurance. Lower satisfaction was linked to experiences involving delays, unexpected adverse events, and the process of collaboration with other health care professionals. Higher satisfaction was reported among women, patients under 30?years, and those with prior chiropractic care. Variation in overall satisfaction and patient experiences could not be fully explained by differences in known patient characteristics.

Conclusion   While patients generally reported very high satisfaction with chiropractic care in Denmark, certain experiences and patient characteristics influenced this perception. Chiropractors should continue to prioritise quality interactions, personalised care, clear communication about risks of adverse events, and effective collaboration with other health care professionals.

Keywords:   Chiropractic care; Patient experiences; Patient interaction; Patient satisfaction; Personalised care; Provider variation.


From the FULL TEXT Article:

Background

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Chiropractic Students Versus Emergency Care Practitioners in Simulated Musculoskeletal Emergencies

By |November 11, 2025|All About Chiropractic, Care Plans, Cervical Disk Herniation, Chiropractic Education, Chiropractic Management, Diagnosis, Escalation of Care, Evidence-based Medicine|

Chiropractic Students Versus Emergency Care Practitioners in Simulated Musculoskeletal Emergencies

The Chiro.Org Blog


SOURCE:   Health SA 2025 (Oct 31): 30: 3195


Ivanna Balanco • Helen Slabber • Christopher Yelverton

Department of Chiropractic,
Faculty of Health Sciences,
University of Johannesburg,
Johannesburg, South Africa.


Background:   As primary contact practitioners, chiropractors and emergency care practitioners (ECPs are first points of access for patients with musculoskeletal (MSK) complaints. A comparison of their diagnostic competency in distinguishing these presentations from underlying emergency pathologies remains an understudied area.

Aim:   To compare the diagnostic abilities of Master of Health Science (MHSc) chiropractic students and ECPs in distinguishing MSK from emergency conditions.

Setting:   The research was conducted at the University of Johannesburg, Faculty of Health Sciences, simulation laboratory.

Methods:   First-year (n = 10) and second-year Master’s (n = 10) chiropractic students and ECPs (n = 10) were assessed using standardised patient scenarios: meningitis, disc herniation and stroke, and assessed on diagnostic assessment, diagnosis and clinical and diagnostic investigation referrals.

Results:   Second-year MHSc students outperformed ECPs in the clinical management of a disc herniation case (Case 2; p < 0.01). Diagnostic accuracy was high (> 90%) for meningitis and stroke across all groups. Differences in investigation preferences emerged, with chiropractic students favouring advanced imaging and ECPs recommending more basic tests. No significant performance differences were found in the other two cases.

Conclusion:   Based on a simulated assessment, chiropractic students demonstrated equivalent competence to emergency care practitioners (ECPs) in diagnosing emergencies, but outperformed them in managing an MSK condition. These preliminary findings suggest chiropractors could contribute to the management of MSK burden in emergency departments.

Contribution:   MHSc chiropractic training enhances diagnostic proficiency in differentiating MSK disorders from emergent pathologies, an important competency for safe and effective practice as primary contact practitioners.

Keywords:   chiropractic; clinical competence; diagnosis; emergency medical services; musculoskeletal disease; simulation.


From the FULL TEXT Article:

Introduction

Musculoskeletal (MSK) conditions represent a significant global health burden, ranking as the second leading cause of disability worldwide and affecting approximately one in five working-age adults (Lowe, Taylor & Hill 2017; Weinstein 2016). Back pain, a prevalent MSK complaint, contributes substantially to reduced work productivity, absenteeism and healthcare costs (Ingram & Symmons 2018; Menke 2003). This high prevalence strains healthcare systems, leading to long wait times for specialist care, including surgery (Joshipura & Gosselin 2020).

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Nociplastic Pain: An Introduction

By |October 21, 2025|Chronic Low Back Pain, Chronic Neck Pain, Chronic Pain, Nociplastic Pain|

Nociplastic Pain: An Introduction

The Chiro.Org Blog


SOURCE:   J Can Chiropr Assoc 2025 (Aug); 69 (2): 131–144

Christopher B. Roecker, DC, MS • Samuel M. Schut, DC

VA Puget Sound Health Care System,
Care Rehabilitation Care Services,
Everett, Washington.



Chronic pain is common in chiropractic practice and often presents without clear evidence of tissue injury. Nociplastic pain is a recently defined concept that highlights altered nociceptive processing within the nervous system. This newer understanding of pain provides insight into chronic conditions such as chronic back or neck pain, chronic headaches, and fibromyalgia. These conditions are commonly encountered in chiropractic practice but may be challenging to address using traditional models. This commentary introduces nociplastic pain, outlining potential mechanisms and relevance to chiropractic care. We advocate a collaborative, multimodal management approach that includes patient education, exercise promotion, and functional goal-setting within a biopsychosocial framework. Understanding nociplastic pain equips chiropractors to support patients with complex chronic pain through compassionate, evidence-based care that addresses the whole person.

Keywords:   back; biopsychosocial; central sensitization; chiropractic; chronic; fibromyalgia; headache; interdisciplinary health teams; management; neck; neuropathic; nociception; nociplastic; pain; widespread chronic pain.


From the FULL TEXT Article:

Introduction

Advances in pain science continue to transform our understanding of pain mechanisms. Traditionally, pain has been mechanistically classified as either nociceptive or neuropathic in nature, and cases that did not fall easily into one of these categories were often labeled as idiopathic or pejoratively suggestive of malingering. [1] This framework, however, was incomplete and left many patients without a clear explanation for their symptoms. By 2017, sufficient evidence had accumulated to describe a third pain mechanistic descriptor (i.e., type of pain), characterized by alterations in nociceptive processing. [2–4] This new understanding of pain is now recognized as nociplastic pain. [5–8]

Table 1

Nociplastic pain is defined as “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain” (Table 1). [5, 8] The purpose of this commentary is to introduce nociplastic pain, its purported pathophysiologic mechanisms, management strategies, and its implications for clinical decision-making within the chiropractic profession.


Nociplastic pain

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LOW BACK PAIN Section and the

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SPINAL PAIN MANAGEMENT Section

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